Serum prostatic specific antigen (PSA) will be elevated in cases of BPH, prostatis, prostatic cancer, and other condtions of prostate. Generally PSA is proportional to increased the size of the transitional zone of the prostate, but the PSA
production
by malignant glands is variable. PSA production is depend on the degree of histologic differentiation in case of prostate cancer, with well-differentiated glands producing more PSA and undifferentiated cancer producing less PSA. Significant
elevations
of PSA, greater than 10 to 20 ng/ml, in the absence of prostatitis, or recent prostatic biopsy are strongly suggestive of cancer of the prostate. Several large scale studies have demonstrated that serum PSA correlates were with advancing clinical
stage,
tumor volume and kpathological stage. We report a case in which high stage and poorly differentiated pathologic grade prostate cancer with low serum PSA level.
|